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- Title
Synthesis of Chiral α‐Substituted β‐Aminophosphine Derivatives through Asymmetric Hydrophosphinylation Utilizing Secondary Phosphine Sulfides.
- Authors
Hirashima, Shin‐ichi; Hirota, Eiki; Matsushima, Yasuyuki; Noda, Naoki; Nishimura, Yuya; Narushima, Takefumi; Nakashima, Kosuke; Miura, Tsuyoshi
- Abstract
The organocatalytic enantioselective hydrophosphinylation of various secondary phosphine sulfides with aromatic and aliphatic nitroalkenes is presented in this study. The reaction produced chiral β‐nitrophosphine sulfides with excellent yields and enantioselectivities (up to 99% yield and 99% ee). Furthermore, the chiral β‐nitrophosphine sulfides can be easily converted into α‐substituted β‐aminophosphine, which is a family of useful P, N‐ligands and phosphine catalysts.
- Subjects
SULFIDES; PHOSPHINE; PHOSPHINES; NITROALKENES; CATALYSTS; ORGANOCATALYSIS
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 24, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200989