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- Title
The Threat of Carbapenem-Resistant Gram-Negative Bacteria in Patients with Hematological Malignancies: Unignorable Respiratory Non-Fermentative Bacteria-Derived Bloodstream Infections.
- Authors
Lu, Linli; Xu, Cong; Tang, Yishu; Wang, Liwen; Cheng, Qian; Chen, Xin; Zhang, Jian; Li, Ying; Xiao, Han; Li, Xin
- Abstract
Background: Carbapenem-resistant Gram-negative bacteria (CRGNB) bloodstream infection (BSI) pose a significant threat to the prognosis of hematologic malignancies (HM) patients. Understanding the distribution of pathogenic bacteria, changes in carbapenem-resistant trends, risk factors for CRGNB infections, and exploring the early detection measures can help reduce mortality. Methods: We conducted a multicenter retrospective study of Gram-negative bacteria (GNB) BSI in patients with HM in three university-affiliated hospitals in Hunan Province, China, from January 2010 to December 2020. Demographic and clinical data were collected from the hospital electronic medical records system. Results: CRGNB caused 138 (15.3%) of 902 GNB BSI. The detection rate of CRGNB increased from 6.4% in 2010– 2012 to 35.4% in 2019– 2020. The 7-day mortality rate was significantly higher in patients with CRGNB BSI than in patients with carbapenem-susceptible Gram-negative bacteria (CSGNB) BSI [31.9% (44/138) vs 9.7% (74/764), P < 0.001], and the mortality rate in patients with carbapenem-resistant non-fermenting bacteria (CRNFB) bloodstream infections was generally higher than that of carbapenem-resistant Enterobacteriaceae (CRE). Urinary catheter (OR, 2.814; CI=1.395– 5.680; P=0.004) and prior exposure to carbapenem (OR, 4.372; CI=2.881– 6.635; P< 0.001) were independent risk factors for CRGNB BSI. Analysis of co-infections showed that 50%– 85% of patients with CRGNB BSI had pulmonary infections, sputum culture results suggested that sputum culture positivity rate was as high as 57.1%– 66.7% in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) and Stenotrophomonas maltophilia BSI, and the results of antimicrobial susceptibility testing of sputum cultures were consistent with the blood cultures. Conclusion: Carbapenem resistance has dramatically increased in HM patients with GNB BSI in recent years and is associated with a worse outcome, especially for non-fermenting bacteria. In high-risk patients, early screening of the respiratory tract specimens may help to detect CRNFB colonization and protect patients from breakthrough BSI.
- Subjects
HUNAN Sheng (China); CARBAPENEM-resistant bacteria; GRAM-negative bacteria; HEMATOLOGIC malignancies; STENOTROPHOMONAS maltophilia; ELECTRONIC health records; RESPIRATORY infections; LUNG infections
- Publication
Infection & Drug Resistance, 2022, Vol 15, p2901
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S359833