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- Title
Numerical Sex Chromosome Aberrations and Abnormal Sex Development in Horse and Sheep.
- Authors
Di Meo, G.P.; Neglia, G.; Perucatti, A.; Genualdo, V.; Iannuzzi, A.; Crocco, D.; Incarnato, D.; Romano, G.; Parma, P.; Iannuzzi, L.
- Abstract
Gonadal dysgenesis and heterosexual conditions are often associated with sex chromosome abnormalities. In this study we report on 2 cases of abnormal sex development involving numerical sex chromosome aberrations in both horse and sheep. A 17-month-old Standardbred filly was sent to an equine fertility centre as an embryo donor due to its reduced size, being much smaller than a racehorse filly of the same age, which excluded it from an athletic career. External genitalia were clinically normal but manual palpation of the reproductive tract showed the presence of a small underdeveloped uterus and ovaries, as confirmed by ultrasonographic examination. Cytogenetic investigation by CBA-banding revealed an abnormal karyotype with X chromosome monosomy (2n = 63,X). A 18-month-old ewe showed distinct heterosexual traits with presence of a vulva (with enlarged clitoris), well-developed abdominal testes and mammary glands. Internal sex adducts were atrophic as seen after mating. Cytogenetic analysis revealed the presence of XX/XY mosaicism. Copyright © 2010 S. Karger AG, Basel
- Publication
Sexual Development, 2010, Vol 3, Issue 6, p329
- ISSN
1661-5425
- Publication type
Article
- DOI
10.1159/000279289