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- Title
Chemical Constituents of the Marine Sponge Aaptos aaptos (Schmidt, 1864) and Their Cytotoxic Activity.
- Authors
Do Thi Trang; Bui Huu Tai; Dan Thuy Hang; Pham Hai Yen; Phan Thi Thanh Huong; Nguyen Xuan Nhiem; Phan Van Kiem
- Abstract
Seven compounds (1-7) were isolated from the marine sponge Aaptos aaptos living in the Vietnamese sea. Their structures were determined as 2 hours, 5H,7H,9H-9S-hydroxy-imidazo[ 1,5-α]pyridine-1,3-dione (1), 3-([9-methylhexadecyl] oxy)propane-1,2-diol 2, 2,3-dihydro-2,3-dioxoaaptamine (3), indol-3-aldehyde (4), methyl indole-3-carboxylate (5) 4-hydroxy-5-(indole-3-yl)-5-oxo-pen tan-2-one (6), and thymidine (7) by extensive analysis of HR-ESI-MS, 1D, and 2D NMR spectral data, as well as by comparison of the spectral data with those reported in the literature. In addition, the absolute configuration of 1 was determined from the experimental ECD spectrum and comparison of this with the theoretical ECD calculations using the TDDFT method. Compounds 1 and 2 were isolated from nature for the first time. Compound 3 induced cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values of 41.27 ± 2.63, 40.70 ± 2.65, 34.31 ± 3.43, and 36.63 ± 1.40 μM, respectively.
- Subjects
SPONGES (Invertebrates); ANTINEOPLASTIC agents; METHANOL; SORBENTS; CARBOXYLATES
- Publication
Natural Product Communications, 2021, Vol 16, Issue 2, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X21993345