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- Title
Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products.
- Authors
Costache, Irina-Iuliana; Miron, Anca; Hăncianu, Monica; Aursulesei, Viviana; Costache, Alexandru Dan; Aprotosoaie, Ana Clara
- Abstract
The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. This review highlights the pharmacokinetic clinically relevant interactions between major conventional cardiovascular medicines and plant products with an emphasis on their putative mechanisms, drawbacks of herbal products use, and the perspectives for further well-designed studies.
- Subjects
PLANT products; DRUG interactions; DRUGS
- Publication
Cardiovascular Therapeutics, 2019, p1
- ISSN
1755-5914
- Publication type
Article
- DOI
10.1155/2019/9402781