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- Title
Small-molecule activation of neuronal cell fate.
- Authors
Schneider, Jay W.; Zhengliang Gao; Shijie Li; Farooqi, Midhat; Tie-Shan Tang; Bezprozvanny, Ilya; Frantz, Doug E.; Hsieh, Jenny
- Abstract
We probed an epigenetic regulatory path from small molecule to neuronal gene activation. Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem cells, rapidly signaling to the neuronal genome via Ca2+ influx. Ca2+-activated CaMK phosphorylated and mediated nuclear export of the MEF2 regulator HDAC5, thereby de-repressing neuronal genes. These results provide new tools to explore the epigenetic signaling circuitry specifying neuronal cell fate and new leads for neuro-regenerative drugs.
- Subjects
NEURAL stem cells; ROBUST control; GENOMES; DEVELOPMENTAL biology; MEDICAL technology; SCIENTIFIC method
- Publication
Nature Chemical Biology, 2008, Vol 4, Issue 7, p408
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.95