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- Title
Immunohistochemical Characteristics of Monocytoid B Cell Lymphoma, Mantle Zone Lymphoma, Small Lymphocytic Lymphoma (or B Chronic Lymphocytic Leukemia), and Hairy Cell Leukemia.
- Authors
Oka, Kuniyuki; Mori, Naoyoshi; Yatabe, Yasushi
- Abstract
Biopsy specimens obtained from 2 patients with monocytoid B cell lymphoma, 7 with mantle zone lymphoma, 7 with small lymphocytic lymphoma or B chronic lymphocytic leukemia, and 6 with hairy cell leukemia were investigated using an immunohistochemical method to detect their immunophenotypic characteristics. Periodate-lysine-paraformaldehyde-fixed frozen biopsies from the lymph node, peripheral blood, bone marrow, spleen, tonsil, lung, and stomach were studied. Monocytoid B cell lymphoma exhibited the immunophenotype of surface(s) IgD-/DRC-1-/Leu-1(CD5)-/Leu-M5(CD11c)-, ± on the neoplastic cells or neoplastic lesions, mantle zone lymphoma exhibited that of sIgD+/DRC-1++/Leu-1-,+/Leu-M5-, small lymphocytic lymphoma or B chronic lymphocytic leukemia that of Leu-1+/sIgD-,+/DRC-1- > +/Leu-M5-, and hairy cell leukemia that of Leu-M5++/sIgD- > > +/Leu-1- > > +/DRC-1-. We therefore suggest that these four types of lymphomas can be differentiated by a combination of anti-sIgD, DRC-1, Leu-1, and Leu-M5 monoclonal antibodies based on their immunophenotypic characteristics. Copyright © 1993 S. Karger AG, Basel
- Publication
Acta Haematologica, 1993, Vol 90, Issue 2, p84
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204381