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- Title
Chemopreventive and Chemosensitizing Effects of Green Tea: An Evidence-based Review.
- Authors
Gul, Sameena; Hassan, Sayyeda Hira; Maryam, Amara; Shakir, Hafiz Abdullah; Khan, Muhammad; Irfan, Muhammad; Shakoori, Farah Rauf; Qazi, Javed Iqbal
- Abstract
Cancer is a major health problem and second foremost cause of death globally. Chemotherapy either targeted or non-targeted is pervasive in the treatment of cancer but due to continuous and repeated doses, cancer cells develop resistance against these chemotherapeutic drugs through multiple mechanisms including MDR1 gene expression. EGCG (Epigallocatechin-3-Gallate) is one of the major polyphenols present in the dry leaves of green tea plant (Camellia sinensis). It has been observed to potentiate the apoptosis and also inhibit cancer cell growth by affecting various signaling molecules and cell cycle regulatory proteins. Clinical studies demonstrated that EGCG treatment of different type of cancers has synergistic effect in combination treatment with other common clinical drugs (cisplatin, taxol, doxorubicin and vinblastine) by modulating chemotherapy response to cancer cells as compared to clinical drugs alone. This review enlightens the possible mechanisms by which EGCG overcome chemo-resistance and recover efficacy of many clinical drugs in various human cancers.
- Subjects
EPIGALLOCATECHIN gallate; CELL cycle proteins; GREEN tea; CANCER cells; CANCER chemotherapy; CANCER cell growth; TEA
- Publication
Pakistan Journal of Zoology, 2022, Vol 54, Issue 5, p2425
- ISSN
0030-9923
- Publication type
Article
- DOI
10.17582/journal.pjz/20191021131001