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- Title
Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine.
- Authors
Kim, Minjee; Kizilbash, Sani H.; Laramy, Janice K.; Gampa, Gautham; Parrish, Karen E.; Sarkaria, Jann N.; Elmquist, William F.
- Abstract
The treatment of metastatic lesions in the brain represents a serious unmet medical need in the field of neuro-oncology. Even though many effective compounds have demonstrated success in treating peripheral (non-CNS) tumors with targeted agents, one aspect of this lack of success in the brain may be related to poor delivery of otherwise effective compounds. Many factors can influence the brain delivery of these agents, but one key barrier is a heterogeneously “leaky” BBB that expresses efflux transporters that limit the BBB permeability for many targeted agents. Future success in therapeutics for brain metastases must take into account the adequate delivery of “active, free drug” to the target, and may include combinations of targeted drugs that are appropriate to address each individual patient’s tumor type. This review discusses some issues that are pertinent to precision medicine for brain metastases, using specific examples of tumor types that have a high incidence of brain metastases.
- Subjects
TREATMENT of brain cancer; BRAIN metastasis; ANTINEOPLASTIC agents; BRAIN cancer; METASTASIS; THERAPEUTICS
- Publication
Pharmaceutical Research, 2018, Vol 35, Issue 9, p1
- ISSN
0724-8741
- Publication type
Article
- DOI
10.1007/s11095-018-2455-9