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Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-03731-9
By:
- Williams, Thomas L.;
- Strachan, Gregory;
- Macrae, Robyn G. C.;
- Kuc, Rhoda E.;
- Nyimanu, Duuamene;
- Paterson, Anna L.;
- Sinha, Sanjay;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
Published in:
2022
By:
- Abraham, George R.;
- Nyimanu, Duuamene;
- Kuc, Rhoda E.;
- Maguire, Janet J.;
- Davenport, Anthony P.;
- Hoole, Stephen P.
Publication type:
journal article
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02453-y
By:
- Williams, Thomas L.;
- Colzani, Maria T.;
- Macrae, Robyn G. C.;
- Robinson, Emma L.;
- Bloor, Stuart;
- Greenwood, Edward J. D.;
- Zhan, Jun Ru;
- Strachan, Gregory;
- Kuc, Rhoda E.;
- Nyimanu, Duuamene;
- Maguire, Janet J.;
- Lehner, Paul J.;
- Sinha, Sanjay;
- Davenport, Anthony P.
Publication type:
Article
HUMAN NEUROMEDIN U-25, A LIGAND FOR THE G-PROTEIN COUPLED ORPHAN FM-3 RECEPTOR, CONSTRICTS HUMAN ARTERIES IN VITRO.
Published in:
British Journal of Pharmacology, 2003, v. 140, p. 28P
By:
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Is urotensin-II the new edothelin?
Published in:
British Journal of Pharmacology, 2002, v. 137, n. 5, p. 579, doi. 10.1038/sj.bjp.0704924
By:
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Vasoconstrictor activity of novel endothelin peptide, ET-1(1 - 31), in human mammary and coronary arteries in vitro.
Published in:
2001
By:
- Maguire, Janet J;
- Kuc, Rhoda E;
- Davenport, Anthony P;
- Maguire, J J;
- Kuc, R E;
- Davenport, A P
Publication type:
journal article
[125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
Published in:
British Journal of Pharmacology, 2001, v. 132, n. 6, p. 1255, doi. 10.1038/sj.bjp.0703939
By:
- Katugampola, Sidath D;
- Maguire, Janet J;
- Matthewson, Stewart R;
- Davenport, Anthony P
Publication type:
Article
Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1.
Published in:
British Journal of Pharmacology, 2000, v. 131, n. 3, p. 441, doi. 10.1038/sj.bjp.0703601
By:
- Maguire, Janet J;
- Kuc, Rhoda E;
- Davenport, Anthony P
Publication type:
Article
Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease.
Published in:
1998
By:
- Maguire, Janet J;
- Davenport, Anthony P;
- Maguire, J J;
- Davenport, A P
Publication type:
journal article
Endothelin converting enzyme (ECE) activity in human vascular smooth muscle.
Published in:
1997
By:
- Maguire, Janet J.;
- Johnson, Christopher M.;
- Mockridge, James W.;
- Davenport, Anthony P.;
- Maguire, J J;
- Johnson, C M;
- Mockridge, J W;
- Davenport, A P
Publication type:
journal article
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.
Published in:
Nature Medicine, 2006, v. 12, n. 9, p. 1075, doi. 10.1038/nm1459
By:
- Clarke, Murray C. H.;
- Figg, Nichola;
- Maguire, Janet J.;
- Davenport, Anthony P.;
- Goddard, Martin;
- Littlewood, Trevor D.;
- Bennett, Martin R.
Publication type:
Article
LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.
Published in:
2015
By:
- Shaikh, Lalarukh Haris;
- Zhou, Junhua;
- Teo, Ada E D;
- Garg, Sumedha;
- Neogi, Sudeshna Guha;
- Figg, Nichola;
- Yeo, Giles S;
- Yu, Haixiang;
- Maguire, Janet J;
- Zhao, Wanfeng;
- Bennett, Martin R;
- Azizan, Elena A B;
- Davenport, Anthony P;
- McKenzie, Grahame;
- Brown, Morris J
Publication type:
journal article
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.588669
By:
- Read, Cai;
- Nyimanu, Duuamene;
- Yang, Peiran;
- Kuc, Rhoda E.;
- Williams, Thomas L.;
- Fitzpatrick, Christopher M.;
- Foster, Richard;
- Glen, Robert C.;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Inotropic Action of the Puberty Hormone Kisspeptin in Rat, Mouse and Human: Cardiovascular Distribution and Characteristics of the Kisspeptin Receptor.
Published in:
PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027601
By:
- Maguire, Janet J.;
- Kirby, Helen R.;
- Mead, Emma J.;
- Kuc, Rhoda E.;
- de Tassigny, Xavier d'Anglemont;
- Colledge, William H.;
- Davenport, Anthony P.
Publication type:
Article
Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction.
Published in:
European Heart Journal, 2020, v. 41, n. 34, p. 3239, doi. 10.1093/eurheartj/ehz915
By:
- Ford, Thomas J;
- Corcoran, David;
- Padmanabhan, Sandosh;
- Aman, Alisha;
- Rocchiccioli, Paul;
- Good, Richard;
- McEntegart, Margaret;
- Maguire, Janet J;
- Watkins, Stuart;
- Eteiba, Hany;
- Shaukat, Aadil;
- Lindsay, Mitchell;
- Robertson, Keith;
- Hood, Stuart;
- McGeoch, Ross;
- McDade, Robert;
- Yii, Eric;
- Sattar, Naveed;
- Hsu, Li-Yueh;
- Arai, Andrew E
Publication type:
Article
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Published in:
British Journal of Clinical Pharmacology, 2022, v. 88, n. 12, p. 5295, doi. 10.1111/bcp.15446
By:
- Nyimanu, Duuamene;
- Chapman, Fiona A.;
- Gallacher, Peter J.;
- Kuc, Rhoda E.;
- Williams, Thomas L.;
- Newby, David E.;
- Maguire, Janet J.;
- Davenport, Anthony P.;
- Dhaun, Neeraj
Publication type:
Article
Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein.
Published in:
Bioscience Reports, 2024, v. 44, n. 7, p. 1, doi. 10.1042/BSR20240528
By:
- Owen, Nicola E.;
- Williams, Thomas L.;
- Maguire, Janet J.;
- Kuc, Rhoda E.;
- Davenport, Emma E.;
- Davenport, Anthony P.
Publication type:
Article
Co-localization of the sodium-glucose co-transporter-2 channel (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal tissue.
Published in:
Bioscience Reports, 2024, v. 44, n. 6, p. 1, doi. 10.1042/BSR20240604
By:
- Williams, Thomas L.;
- Kuc, Rhoda E.;
- Paterson, Anna L.;
- Abraham, George R.;
- Pullinger, Anna L.;
- Maguire, Janet J.;
- Sinha, Sanjay;
- Greasley, Peter J.;
- Ambery, Philip;
- Davenport, Anthony P.
Publication type:
Article
The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro.
Published in:
Cardiovascular Research, 2014, v. 101, n. 3, p. 513, doi. 10.1093/cvr/cvt333
By:
- Maguire, Janet J.;
- Jones, Katie L.;
- Kuc, Rhoda E.;
- Clarke, Murray C.H.;
- Bennett, Martin R.;
- Davenport, Anthony P.
Publication type:
Article
Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system.
Published in:
Cardiovascular Research, 2009, v. 81, n. 2, p. 353
By:
- John D. Mitchell;
- Janet J. Maguire;
- Rhoda E. Kuc;
- Anthony P. Davenport
Publication type:
Article
Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
Published in:
Cardiovascular Research, 2006, v. 69, n. 1, p. 227, doi. 10.1016/j.cardiores.2005.09.001
By:
- Kleinz, Matthias J.;
- Maguire, Janet J.;
- Skepper, Jeremy N.;
- Davenport, Anthony P.
Publication type:
Article
Endothelin-Mediated Vasoconstriction in Early Atherosclerosis Is Markedly Increased in ApoE −/− Mouse but Prevented by Atorvastatin.
Published in:
Experimental Biology & Medicine, 2006, v. 231, n. 6, p. 806, doi. 10.3181/00379727-231-2310806
By:
- Maguire, Janet J.;
- Wiley, Katherine E.;
- Kuc, Rhoda E.;
- Stoneman, Victoria E. A.;
- Bennett, Martin R.;
- Davenport, Anthony P.
Publication type:
Article
Quantification of Endothelin Receptor Subtypes in Peripheral Tissues Reveals Downregulation of ETA Receptors in ETB-Deficient Mice.
Published in:
Experimental Biology & Medicine, 2006, v. 231, n. 6, p. 741, doi. 10.3181/00379727-231-2310741
By:
- Kuc, Rhoda E.;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-56157-9
By:
- Nyimanu, Duuamene;
- Kay, Richard G.;
- Sulentic, Petra;
- Kuc, Rhoda E.;
- Ambery, Philip;
- Jermutus, Lutz;
- Reimann, Frank;
- Gribble, Fiona M.;
- Cheriyan, Joseph;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
[Pyr¹]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr¹]Apelin-13.
Published in:
Frontiers in Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnins.2017.00092
By:
- Yang, Peiran;
- Kuc, Rhoda E.;
- Brame, Aimée L.;
- Dyson, Alex;
- Singer, Mervyn;
- Glen, Robert C.;
- Cheriyan, Joseph;
- Wilkinson, Ian B.;
- Davenport, Anthony P.;
- Maguire, Janet J.
Publication type:
Article
Targeting the apelin system for the treatment of cardiovascular diseases.
Published in:
Cardiovascular Research, 2023, v. 119, n. 17, p. 2683, doi. 10.1093/cvr/cvad171
By:
- Chapman, Fiona A;
- Maguire, Janet J;
- Newby, David E;
- Davenport, Anthony P;
- Dhaun, Neeraj
Publication type:
Article
Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes.
Published in:
Cardiovascular Research, 2023, v. 119, n. 2, p. 587, doi. 10.1093/cvr/cvac065
By:
- Macrae, Robyn G C;
- Colzani, Maria T;
- Williams, Thomas L;
- Bayraktar, Semih;
- Kuc, Rhoda E;
- Pullinger, Anna L;
- Bernard, William G;
- Robinson, Emma L;
- Davenport, Emma E;
- Maguire, Janet J;
- Sinha, Sanjay;
- Davenport, Anthony P
Publication type:
Article
Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
Published in:
Journal of the American Heart Association, 2016, v. 5, n. 10, p. 1, doi. 10.1161/JAHA.116.004421
By:
- Kennedy, Amanda J.;
- Yang, Peiran;
- Read, Cai;
- Kuc, Rhoda E.;
- Yang, Lucy;
- Taylor, Emily J. A.;
- Taylor, Colin W.;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29.
Published in:
British Journal of Pharmacology, 2020, v. 177, n. 21, p. 4942, doi. 10.1111/bph.15094
By:
- Alexander, Steve P.H.;
- Armstrong, Jane F.;
- Davenport, Anthony P.;
- Davies, Jamie A.;
- Faccenda, Elena;
- Harding, Simon D.;
- Levi‐Schaffer, Francesca;
- Maguire, Janet J.;
- Pawson, Adam J.;
- Southan, Christopher;
- Spedding, Michael
Publication type:
Article
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29.
Published in:
2020
By:
- Alexander, S P H;
- Armstrong, J;
- Davenport, A P;
- Davies, J;
- Faccenda, E;
- Harding, S D;
- Levi-Schaffer, F;
- Maguire, J J;
- Pawson, A J;
- Southan, C;
- Spedding, M J;
- Alexander, Steve P H;
- Armstrong, Jane F;
- Davenport, Anthony P;
- Davies, Jamie A;
- Faccenda, Elena;
- Harding, Simon D;
- Levi-Schaffer, Francesca;
- Maguire, Janet J;
- Pawson, Adam J
Publication type:
journal article
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Published in:
2019
By:
- Yang, Peiran;
- Read, Cai;
- Kuc, Rhoda E.;
- Nyimanu, Duuamene;
- Williams, Thomas L.;
- Crosby, Alexi;
- Buonincontri, Guido;
- Southwood, Mark;
- Sawiak, Stephen J.;
- Glen, Robert C.;
- Morrell, Nicholas W.;
- Davenport, Anthony P.;
- Maguire, Janet J.
Publication type:
journal article
The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan.
Published in:
Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1369489
By:
- Williams, Thomas L.;
- Nyimanu, Duuamene;
- Kuc, Rhoda E.;
- Foster, Richard;
- Glen, Robert C.;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer.
Published in:
British Journal of Pharmacology, 2013, v. 168, n. 2, p. 283, doi. 10.1111/j.1476-5381.2011.01786.x
By:
- Ling, Lowell;
- Maguire, Janet J;
- DavENport, Anthony P
Publication type:
Article
Modulation of the apelin/APJ system in heart failure and atherosclerosis in man.
Published in:
2010
By:
- Pitkin, Sarah L;
- Maguire, Janet J;
- Kuc, Rhoda E;
- Davenport, Anthony P
Publication type:
journal article
Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.
Published in:
2010
By:
- Johnström, Peter;
- Fryer, Tim D;
- Richards, Hugh K;
- Maguire, Janet J;
- Clark, John C;
- Pickard, John D;
- Davenport, Anthony P;
- Johnström, Peter
Publication type:
journal article
Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation.
Published in:
British Journal of Pharmacology, 2006, v. 147, n. 6, p. 612, doi. 10.1038/sj.bjp.0706503
By:
- Gardiner, Sheila M.;
- March, Julie E.;
- Kemp, Philip A.;
- Maguire, Janet J.;
- Kuc, Rhoda E.;
- Davenport, Anthony P.;
- Bennett, Terence
Publication type:
Article
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Published in:
Frontiers in Endocrinology, 2023, v. 14, p. 1, doi. 10.3389/fendo.2023.1139121
By:
- Williams, Thomas L.;
- Macrae, Robyn G. C.;
- Kuc, Rhoda E.;
- Brown, Alastair J. H.;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma.
Published in:
Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1379658
By:
- Williams, Thomas L.;
- Nwokoye, Peter;
- Kuc, Rhoda E.;
- Smith, Kieran;
- Paterson, Anna L.;
- Allinson, Kieren;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma.
Published in:
Frontiers in Neuroscience, 2024, p. 01, doi. 10.3389/fnins.2024.1379658
By:
- Williams, Thomas L.;
- Nwokoye, Peter;
- Kuc, Rhoda E.;
- Smith, Kieran;
- Paterson, Anna L.;
- Allinson, Kieren;
- Maguire, Janet J.;
- Davenport, Anthony P.
Publication type:
Article
Discovery of a Competitive Apelin Receptor (APJ) Antagonist.
Published in:
ChemMedChem, 2011, v. 6, n. 6, p. 1017, doi. 10.1002/cmdc.201100069
By:
- Macaluso, N. J. Maximilian;
- Pitkin, Sarah L.;
- Maguire, Janet J.;
- Davenport, Anthony P.;
- Glen, Robert C.
Publication type:
Article
L-683,877: Pharmacological profile of a novel 5-HT3 receptor antagonist.
Published in:
Drug Development Research, 1992, v. 25, n. 1, p. 17, doi. 10.1002/ddr.430250103
By:
- Tattersall, David;
- Newberry, Nigel;
- Beer, Margaret S.;
- Rigby, Mike;
- Gilbert, Michael;
- Maguire, Janet J.;
- Mudunkotuwa, Nikki;
- Duchnowski, Mark;
- McKnight, Alexander T.;
- Swain, Christopher J.;
- Kneen, Clare;
- Dourish, Colin T.
Publication type:
Article
Apelin peptides linked to anti‐serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, p. 96, doi. 10.1111/bcpt.13227
By:
- Read, Cai;
- Yang, Peiran;
- Kuc, Rhoda E.;
- Nyimanu, Duuamene;
- Williams, Thomas L.;
- Glen, Robert C.;
- Holt, Lucy J.;
- Arulanantham, Haren;
- Smart, Andrew;
- Davenport, Anthony P.;
- Maguire, Janet J.
Publication type:
Article

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