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- Title
DOENÇA DE BEHÇET -- INFLIXIMAB NO TRATAMENTO DAS MANIFESTAÇÕES MUCOCUTÂNEAS.
- Authors
Lestre, Sara; Trindade, Felicidade; Martins, Andrea; Baptista, Juliana; Feio, Ana Barata; Lopes, Maria João Paiva
- Abstract
Behçet's disease (BD) is chronic, relapsing and multisystem inflammatory disorder, whose diagnosis is essentially clinical. In recent studies, the antagonists of tumor necrosis factor alpha have shown good results in the treatment of mucocutaneous manifestations of BD. The authors describe three cases of BD with serious mucocutaneous involvement treated with infliximab. Clinical case I:A 16-year-old female patient with an 8-year history of severe bipolar aphtosis. A rapid clinical response to biological therapy was verifed, with partial and total remission of ulcers at 2nd and 6th week of treatment, respectively. Clinical Case 2: A 56-year-old female patient with chronic nodular panniculitis of lower limbs, arthralgias and orogenital ulceration. After 6 weeks of treatment with infliximab, a complete clinical remission was observed. Clinical ease 3: A 50-year-old female with a 15- year history of relapsing oropharyngeal ulceration. A good clinical response to biologic therapy was observed. At 22nd week it was interrupted because frequent dental abscesses. In our experience, infliximab is an effective therapeutic alternative that should be considered in the presence of mucocutaneous manifestations resistant to conventional therapies.
- Subjects
BEHCET'S disease; TUMOR necrosis factors; INFLIXIMAB; WOMEN patients; ALTERNATIVE medicine
- Publication
Acta Reumatológica Portuguesa, 2009, Vol 34, Issue 4, p633
- ISSN
0303-464X
- Publication type
Case Study