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- Title
Association between pulse pressure and ischaemic stroke in elderly patients with hypertension.
- Authors
Jiayi Huang; Lin Liu; Yu-Qing Huang; Lo, Kenneth; Yu-Ling Yu; Chao-Lei Chen; Song-tao Tang; Bin Zhang; Ying Qing Feng; Huang, Jiayi; Liu, Lin; Huang, Yu-Qing; Yu, Yu-Ling; Chen, Chao-Lei; Tang, Song-Tao; Zhang, Bin; Feng, Ying Qing
- Abstract
<bold>Background: </bold>The association between pulse pressure (PP) and the risk of first ischaemic stroke (IS) is inconsistent. Therefore, we evaluated the association between PP and the risk of first IS among elderly hypertensive population in China.<bold>Methods: </bold>This was a retrospective cohort study. Patients with hypertension and aged ≥60 years were recruited. Multivariate Cox regression was performed to evaluate the association between PP and the risk of IS. We further stratified the regression models into subgroups and test for interaction to assess whether the associations were modified by other covariates.<bold>Results: </bold>A total of 3315 patients with hypertension (44.49% male; mean age 71.41±7.20 years) were included, and 206 cases of IS occurred with a median follow-up of 5.5 years. The results showed that per SD mm Hg increment in PP was associated with a 17% (95% CI 1.05 to 1.40, p=0.0172) increased risk of IS. Moreover, the HR of IS for the highest quartile of PP was 1.46 (95% CI 1.18 to 1.73, p=0.0011, p for trend <0.001) comparing with the lowest quartile of PP. Subgroup analysis showed that population aged ≥70 years, male, patients with smoking or drinking habit, diabetes at baseline, being overweight, with uncontrolled blood pressure or did not take antihypertensive drugs have a higher risk for IS.<bold>Conclusions: </bold>We found that PP was significantly associated with IS and was an independent risk factor for IS.
- Subjects
ISCHEMIC stroke; OLDER patients; HYPERTENSION; STROKE patients; DYSLIPIDEMIA; STROKE; MEDICAL sciences
- Publication
Postgraduate Medical Journal, 2021, Vol 97, Issue 1146, p222
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-137357