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- Title
Fabrication of electrospun antioxidant nanofibers by rutin-pluronic solid dispersions for enhanced solubility.
- Authors
Lee, Il Woo; Li, Jinglei; Chen, Xiguang; Park, Hyun Jin
- Abstract
ABSTRACT In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44859.
- Subjects
ANTIOXIDANTS; NANOFIBERS; RUTIN; PULLULANASE; ELECTROSPINNING; DRUG delivery systems; SCANNING electron microscopy
- Publication
Journal of Applied Polymer Science, 2017, Vol 134, Issue 21, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.44859