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- Title
Synthesis of chitosan derivative with dual-antibacterial functional groups and its antibacterial activity.
- Authors
Li, Zhihan; Yang, Fei; Yang, Rendang
- Abstract
ABSTRACT The O-fumaryl ester (OFTMCS) of N,N,N-trimethyl chitosan (TMCS) has been synthesized as a water-soluble chitosan (CS) derivative bearing dual-functional groups, with the aim of discovering novel CS derivatives with good water solubility and enhanced the antibacterial activity compared with unmodified CS. OFTMCS was characterized by FT-IR, 13C NMR, XPS, XRD and Zeta potential analyses. The XPS results indicated that the degree of substitution (DS) on the C2-NH2 group of the CS was 0.78, and that the DS on its C6-OH group was 0.31. The TGA results showed that the thermal stability of OFTMCS was lower than that of unmodified CS. The antibacterial activities of OFTMCS were investigated by assessing the mortality rates of the representative Gram-positive and Gram-negative bacteria Staphylococcus aureus and Escherichia coli, respectively. The results indicated that OFTMCS exhibited superior antibacterial activity to CS at a lower dosage. The synthesis of CS derivatives bearing dual-functional groups could therefore be used as a promising strategy to enhance the antibacterial activity of CS. The antimicrobial mechanism of action of OFTMCS was discussed. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42663.
- Subjects
ANTIBACTERIAL agents; CHITOSAN; BIOMATERIALS; THERMAL stability; X-ray diffraction; ZETA potential
- Publication
Journal of Applied Polymer Science, 2015, Vol 132, Issue 43, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.42663