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- Title
Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment.
- Authors
Bulatović, Mirna Z.; Maksimović‐Ivanić, Danijela; Bensing, Christian; Gómez‐Ruiz, Santiago; Steinborn, Dirk; Schmidt, Harry; Mojić, Marija; Korać, Aleksandra; Golić, Igor; Pérez‐Quintanilla, Damian; Momčilović, Miljana; Mijatović, Sanja; Kaluđerović, Goran N.
- Abstract
The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death.
- Subjects
ORGANOTIN compounds; MESOPOROUS materials; BIOMEDICAL materials; CANCER treatment; ANTINEOPLASTIC agents; MELANOCYTES
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 23, p5982
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201400763