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- Title
miR-101 Represses T-Cell Acute Lymphoblastic Leukemia by Targeting CXCR7/STAT3 Axis.
- Authors
Xue-Yi Yang; Ye Sheng
- Abstract
Although miR-101 is involved in the development and progression of T-cell acute lymphoblastic leukemia (T-ALL), the underlying molecular mechanisms remain unclear. In this article, we report that miR-101 expression was inversely correlated with CX chemokine receptor 7 (CXCR7) level in T-ALL. Introducing miR-101 inhibited T-ALL cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis in vivo. CXCR7 was identified as a direct target of miR-101. The inhibitory effects of miR-101 were mimicked and counteracted by CXCR7 depletion and overexpression, respectively. Mechanistically, miR-101 targets CXCR7/STAT3 axis to reduce T-ALL growth and metastasis. Overall, these findings implied the potential application of miR-101 and CXCR7 in T-ALL treatment.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; LUNG cancer; CHEMOKINE receptors; TUMOR growth
- Publication
Oncology Research, 2019, Vol 27, Issue 9, p997
- ISSN
0965-0407
- Publication type
Article
- DOI
10.3727/096504018X15439207752093