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- Title
Expression of Chemerin Correlates With a Favorable Prognosis in Patients With Non-Small Cell Lung Cancer.
- Authors
Shen Zhao; Chao Li; Yun-bin Ye; Feng Peng; Qiang Chen
- Abstract
Objective: Chemerin was shown to play a role in the colocalization of natural killer (NK) cells, which have an antitumor role. We aimed to determine the expression of chemerin and the relationship of chemerin expression with prognosis in patients with non-small cell lung cancer (NSCLC). Methods: We examined chemerin expression and the infiltration number of NK cells in NSCLC patients using immunohistochemistry. The association of chemerin expression with clinicopathologic characteristics and prognosis was analyzed. Results: Of the NSCLC patients, 51.85% exhibited lower expression levels of chemerin protein. The chemerin expression was significantly correlated with histological grade and the infiltration of NK cells. Non-small cell lung cancer patients with a lower chemerin expression had poorer survival rates than those with a higher expression. Multi-variable Cox regression analysis revealed that the chemerin expression level was an independent factor for prognosis. Conclusions: A greater expression of chemerin is an independent predictor of a better prognosis for patients with NSCLC.
- Subjects
CONFIDENCE intervals; GROWTH factors; IMMUNOHISTOCHEMISTRY; KILLER cells; LUNG cancer; PROBABILITY theory; PROGNOSIS; STATISTICS; SURVIVAL analysis (Biometry); TUMOR markers; DATA analysis; PROPORTIONAL hazards models; DATA analysis software
- Publication
Laboratory Medicine, 2011, Vol 42, Issue 9, p553
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LMWW79NITS6ZADPT