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- Title
The effect of Voxelotor on quantitation of HbS levels by high‐performance liquid chromatography in a patient with sickle cell disease.
- Authors
Giacomini, Luca; Puricelli, Chiara; Sacchetti, Sara; Zanotti, Valentina; Rolla, Roberta
- Abstract
The article focuses on the impact of Voxelotor, an oral sickle hemoglobin inhibitor, on the quantitation of HbS levels in a patient with sickle cell disease. Topics include the patient's clinical presentation, the challenges in accurately quantifying HbS levels using high-performance liquid chromatography (HPLC) due to Voxelotor treatment, and the importance of providing information about the patient's drug treatment to ensure proper laboratory test interpretation.
- Subjects
DRUG therapy for sickle cell anemia; HEMOGLOBINOPATHY diagnosis; DRUG efficacy; ANTISICKLING agents; HEMOGLOBINS; HIGH performance liquid chromatography; BILE pigments; PHLEBOTOMY; BLOOD transfusion; TRANSFERASES; OXIDOREDUCTASES; PHARMACODYNAMICS
- Publication
International Journal of Laboratory Hematology, 2023, Vol 45, Issue 6, p831
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/ijlh.14153