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- Title
High-efficiency, high-flux in-line hemofiltration using a high blood flow extracorporeal circuit.
- Authors
Grazioli, Alison; Shah, Sanjeev R; Rabin, Joseph; Shah, Rashmikant; Madathil, Ronson J; King, Joshua D; DiChiacchio, Laura; Rector, Raymond P; Deatrick, Kristopher B; Wu, Zhongjun J; Herr, Daniel L
- Abstract
The ability of current renal replacement therapy modalities to achieve rapid solute removal is limited by membrane surface area and blood flow rate. Extracorporeal membrane oxygenation offers high blood flow and hemodynamic support that may be harnessed to overcome limitations in traditional renal replacement therapy. Using an extracorporeal membrane oxygenation circuit, we describe a high blood flow, high-efficiency hemofiltration technique using in-line hemofilters (hemoconcentrators) and standard replacement fluid to enhance solute clearance. Using this approach and a total of 5 L of replacement volume per treatment, creatinine (Cr) clearances of 8.3 L/hour and 11.2 L/hour using one and two hemoconcentrators, respectively, were achieved. With use of a high blood flow rate of up to 5 L/min, this hemofiltration technique can potentially offer clearance of 30 times that of continuous renal replacement therapy and of 6 times that of hemodialysis which may expand the ability to remove substances traditionally not considered removable via existing extracorporeal therapies.
- Subjects
BLOOD circulation; BLOOD filtration; CREATININE; ELECTROLYTES; EXTRACORPOREAL membrane oxygenation; HEMODIALYSIS; HEMODYNAMICS
- Publication
Perfusion, 2020, Vol 35, Issue 4, p351
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659119871232