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- Title
Catalytic Asymmetric Synthesis of Dihydropyrido[1,2- a]indoles from Nitrones and Allenoates.
- Authors
Pace, Wiktoria H.; Mo, Dong-Liang; Reidl, Tyler W.; Wink, Donald J.; Anderson, Laura L.
- Abstract
An asymmetric method for the synthesis of dihydropyrido[1,2- a]indoles from mixtures of nitrones and allenoates has been developed. This transformation showcases the use of squaramide catalysis in a complicated cascade system that has been shown to be highly sensitive to reaction conditions and substituent effects. The new method provides access to enantiomerically enriched dihydropyridoindoles from modular, non-indole reagents. The optimization and scope of the new transformation is discussed in addition to initial mechanistic experiments that indicate the role of the catalyst.
- Subjects
ASYMMETRIC synthesis; DIHYDROPYRIDINE; INDOLE; HETEROCYCLIC compounds synthesis; NITRONE derivatives; CATALYSIS synthesis
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 32, p9183
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201602568