We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Alkylation of Azoles.
- Authors
Ohmiya, Hirohisa; Zhang, Heng; Shibata, Saori; Harada, Ayumi; Sawamura, Masaya
- Abstract
Copper-catalyzed enantioselective allylic alkylation of azoles with γ,γ-disubstituted primary allylic phosphates was achieved using a new chiral N-heterocyclic carbene ligand bearing a naphtholic hydroxy group. This reaction occurred with excellent branch regioselectivity and high enantioselectivity, thus forming a controlled all-carbon quaternary stereogenic center at the position α to the heteroaromatic ring.
- Subjects
MOLECULAR structure of azoles; ENANTIOSELECTIVE catalysis; COPPER catalysts; ALKYLATION; CHEMICAL reactions; QUATERNARY structure
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 15, p4777
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201600619