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- Title
Double Transfer of Chirality in Organocopper-Mediated bis(Alkylating) Cycloisomerization of Enediynes.
- Authors
Campolo, Damien; Arif, Tanzeel; Borie, Cyril; Mouysset, Dominique; Vanthuyne, Nicolas; Naubron, Jean‐Valère; Bertrand, Michèle P.; Nechab, Malek
- Abstract
An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo-, regio-, diastereo-, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central-to-axial-to-central) is observed.
- Subjects
CHIRALITY; ORGANOCOPPER compounds; CYCLOISOMERIZATION; ENEDIYNES; CHEMICAL reagents; ENANTIOSELECTIVE catalysis
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 12, p3227
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201310530