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- Title
Preliminary study on DNA damage of ZrO<sub>2</sub>/LaPO<sub>4</sub> diphase ceramics on human peripheral blood lymphocytes in vitro.
- Authors
ZHU Hui-fang; CHEN Li-ping; ZHANG Xiu-li; ZHANG Bao-wei
- Abstract
PURPOSE: To detect the genotoxicity of dental machinable ZrO2/LaPO4 diphase ceramics on human peripheral blood lymphocytes in vitro. METHODS: The evaluation of DNA damage on human lymphocytes was performed by comet assay for three groups of ZrO2/LaPO4 diphase ceramics with 30wt% of LaPO4 (with 3wt% and 5wt% of Y2O3) and 40wt% of LaPO4 (with 5wt% of Y2O3). The results were analyzed with SPSS16.0 software package for one-factor ANOVA and LSD. RESULTS: Three experimental groups with different concentration of LAPO4 of ZrO2/LaP4 diphase ceramics, the negative control of IPS Empress II ceramics and the blank behaved little migration of the DNA strands respectively after six-day test, and there was no significant difference in all the groups except the positive control (P>0.05). CONCLUSION: The study- indicates little effect of DNA damage of ZrO2/LaPO4 diphase ceramics.
- Subjects
DENTAL ceramics; GENETIC toxicology; DNA damage; LYMPHOCYTES; ZIRCONIUM oxide; PHOSPHATES
- Publication
Shanghai Journal of Stomatology, 2009, Vol 18, Issue 3, p291
- ISSN
1006-7248
- Publication type
Article