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- Title
Erythrocyte mean corpuscular volume during cytotoxic therapy is a predictive parameter of secondary leukemia in Hodgkin's disease.
- Authors
De Gramont, Aimery; Louvet, Christophe; Krulik, Marcel; Smadja, Nicole; Donadio, Daniel; Laporte, Jean Philippe; Brissaud, Philippe; Delǎge, Jean-Marie; Drolet, Yvan; Rioux, Ernest; Jacquillat, Claude; Najman, Albert; Parlier, Yolaine; Boiron, Michel; Debray, Jacques; de Gramont, A; Louvet, C; Krulik, M; Smadja, N; Donadio, D
- Abstract
Mean corpuscular volume (MCV) evolution during cytotoxic therapy was studied in 32 patients with Hodgkin's disease (HD) who developed therapy-related acute nonlymphocytic leukemia (t-ANLL) and in 64 HD controls matched for age, therapy duration, and MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) administration. Maximum MCV during therapy reached 108.3 +/- 8.2 fl in t-ANLL patients and 103.4 +/- 9.1 fl in the controls (P = 0.001). Maximum MCV increase was 26.7 +/- 8.3 fl in t-ANLL patients and 16.6 +/- 8.3 fl in the controls (P = 10(-9). The greatest 3-month increase observed during therapy was 14.8 +/- 6 fl in the t-ANLL patients and 10.1 +/- 4.8 fl in the controls (P = 0.0001). During initial MOPP therapy, the greatest 3-month increase reached 14.1 +/- 5.3 fl in t-ANLL patients and 9.8 +/- 4.5 fl in the controls (P = 0.01). The relative risk of developing t-ANLL was 9 for a MCV maximum increase over 24 fl during therapy, which was observed in 71% of the patients with t-ANLL and in only 22% of the controls. For the greatest 3-month MCV increase over 15 fl observed in 57% of the t-ANLL patients and in 17% of the controls, the relative risk reached 15. This suggests that there is at least one factor, independent from therapy, which predisposes to t-ANLL. MCV evolution during therapy appears useful in determining which HD patients have a high risk of developing t-ANLL.
- Publication
Cancer (0008543X), 1987, Vol 59, Issue 2, p301
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870115)59:2<301::AID-CNCR2820590222>3.0.CO;2-W