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- Title
Pancreatic polypeptide in islet cell tumors. Morphologic and functional correlations.
- Authors
Tomita, Tatsuo; Kimmel, Joe R.; Friesen, Stanley R.; Doull, Vera; Pollock, H. Gail; Tomita, T; Kimmel, J R; Friesen, S R; Doull, V; Pollock, H G
- Abstract
Twelve islet cell tumors and one islet cell hyperplasia were studied with immunocytochemical and radioimmunoassay methods. With immunocytochemical staining, all six insulinomas, one mixed insulinoma-glucagonoma, and four gastrinomas were positive for insulin, insulin and glucagon, and gastrin, respectively. Pancreatic polypeptide (PP) was positive in three insulinomas and one mixed insulinoma-glucagonoma. All of the tumors were positive for neuron-specific enolase (NSE). Radioimmunoassays of tissue extracts further disclosed that all functioning tumors contained more than one pancreatic hormone. PP concentrations of two insulinomas and one mixed insulinoma-glucagonoma were higher than that of normal control pancreases. A study of protein meal-stimulated PP secretion revealed that three of the insulinoma cases and two gastrinoma cases exhibited higher plasma PP levels than the age-matched controls. The findings suggest that: both functioning and nonfunctioning islet cell tumors derive from neuroendocrine cells positive for NSE; all functioning islet cell tumors appear to contain PP in the tumor tissue as a minor component; as many as 70% of the patients with islet cell tumors present with abnormally higher plasma PP levels after protein meals; and a study of meal-stimulated PP secretion may well be used as a marker for the presence of functional islet cell tumors.
- Publication
Cancer (0008543X), 1985, Vol 56, Issue 7, p1649
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19851001)56:7<1649::AID-CNCR2820560731>3.0.CO;2-3