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- Title
Epidermal Hyperproliferation Assessed by the Monoclonal Antibody K<sub>s</sub>8.12 on Frozen Sections.
- Authors
de Mare, Saskia; Van Erp, Piet E.J.; van de Kerkhof, Peter C. M.
- Abstract
Using the monoclonal antibody Ks,8. 12 directed against keratins 13 and 16, we have studied psoriatic and trauma-induced hyperproliferation. In normal skin 40 and 64 h after sellotape stripping and in psoriatic lesions, a pronounced suprabasal staining by Ks8.12 was observed. In unstripped normal skin and in the clinically uninvolved skin of psoriatic patients some patchy staining limited to the basal layer was seen. The clear distinction between normal and hyperproliferative skin in keratin expression as detected by Ks8.12 indicates that this antibody may serve as a marker for epidermal proliferation in psoriasis.
- Subjects
EPIDERMIS; IMMUNOGLOBULINS; KERATIN; PSORIASIS; SKIN diseases; BLOOD proteins
- Publication
Journal of Investigative Dermatology, 1989, Vol 92, Issue 1, p130
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep13071345