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- Title
Long-term trends in incidence, characteristics and prognosis of screen-detected and interval cancers in women participating in the Dutch breast cancer screening programme.
- Authors
ten Velde, Daniëlle E.; Duijm, Lucien E. M.; van der Sangen, Maurice J. C.; Schipper, Robert-Jan; Tjan-Heijnen, Vivianne C. G.; Vreuls, Willem; Strobbe, Luc J. A.; Voogd, Adri C.
- Abstract
Background: No studies are available in which changes over time in characteristics and prognosis of patients with interval breast cancers (ICs) and screen-detected breast cancers (SDCs) have been compared. The aim was to study these trends between 1995 and 2018. Methods: All women with invasive SDCs (N = 4290) and ICs (N = 1352), diagnosed in a southern mammography screening region in the Netherlands, were included and followed until date of death or 31 December 2022. Results: The 5-year overall survival rate of women with SDCs increased from 91.4% for those diagnosed in 1995–1999 to 95.0% for those diagnosed in 2013–2018 (P < 0.001), and from 74.8 to 91.6% (P < 0.001) in the same periods for those with ICs. A similar trend was observed for the 10-year survival rates. After adjustment for changes in tumour characteristics, the hazard ratio (HR) for overall survival was 0.47 (95% confidence interval (CI): 0.38–0.59) for women with SDCs diagnosed in the period 2013–2018, compared to the women diagnosed in the period 1995–1999. For the women with ICs this HR was 0.27 (95% CI: 0.19–0.40). Conclusion: The prognosis of women with ICs has improved rapidly since 1995 and is now almost similar to that of women with SDCs.
- Publication
British Journal of Cancer, 2024, Vol 130, Issue 9, p1561
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/s41416-024-02633-7