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- Title
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
- Authors
Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Sakashita, Masafumi; Yamada, Takechiyo; Fujieda, Shigeharu; Tanaka, Shota; Doi, Satoru; Miyatake, Akihiko; Enomoto, Tadao; Nishiyama, Chiharu; Nakano, Nobuhiro; Maeda, Keiko; Okumura, Ko; Ogawa, Hideoki; Ikeda, Shigaku; Noguchi, Emiko; Sakamoto, Tohru
- Abstract
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (Pcombined = 8.36 × 10?18), the major histocompatibility complex (MHC) region (P = 8.38 × 10?20), OR10A3-NLRP10 (P = 1.54 × 10?22), GLB1 (P = 2.77 × 10?16), CCDC80 (P = 1.56 × 10?19), CARD11 (P = 7.83 × 10?9), ZNF365 (P = 5.85 × 10?20) and CYP24A1-PFDN4 (P = 1.65 × 10?8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
- Subjects
GENOMES; DISEASE susceptibility; ATOPIC dermatitis; POPULATION genetics; LOCUS (Genetics); HISTOCOMPATIBILITY; JAPANESE people
- Publication
Nature Genetics, 2012, Vol 44, Issue 11, p1222
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2438