We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
- Authors
van Heel, David A.; Franke, Lude; Hunt, Karen A.; Gwilliam, Rhian; Zhernakova, Alexandra; Inouye, Mike; Wapenaar, Martin C.; Barnardo, Martin C. N. M.; Bethel, Graeme; Holmes, Geoffrey K. T.; Feighery, Con; Jewell, Derek; Kelleher, Dermot; Kumar, Parveen; Travis, Simon; Walters, Julian R. F.; Sanders, David S.; Howdle, Peter; Swift, Jill; Playford, Raymond J.
- Abstract
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10−7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10−14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
- Subjects
UNITED Kingdom; GENOMES; CELIAC disease; DISEASE risk factors; GENETIC markers; CELL proliferation; GENETIC polymorphisms
- Publication
Nature Genetics, 2007, Vol 39, Issue 7, p827
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng2058