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- Title
Macrophages and Dendritic Cells during the Early Stages of Antigen-Induced Arthritis in Rats: Immunohistochemical Analysis of Cryostat Sections of the Whole Knee Joint.
- Authors
Verschure, P. J.; Van Noorden, C. J. F.; Dijkstra, C. D.
- Abstract
This appearance of different macrophage subpopulation, Ia-positvie antigen-presenting dendritic cells and of T and B lymphocytes was studied in early phases of antigen-induced arthritis in rat knee joints. Cryostat sections of whole knee joints were analysed with immunohistochemical techniques using monoclonal antibodies against rat macrophages. Ia-antigen, and lymphocyte subpopulations. The results showed that in the early phases of the development of arthritis, the synovium was already infiltrated by many monocytes, young macrophages, granulocytes, penvascular Ia-positive non-lymphosal cells, some mature tissue macrophages, and only few T lymphocytes. In later phases not only monocytes, young macrophages and Ia-positive cells became more prominent but also the more mature ED2 positive macrophages and the ED3 positive macrophages that are normally confined to lymphoid organs became increasingly important. The T-cell population increased to some extent in later phases of arthritis induction, possibly induced by clustering with the Ia-positive cells.
- Subjects
KNEE; KILLER cells; MACROPHAGES; JOINT diseases; LEUCOCYTES; CELLS
- Publication
Scandinavian Journal of Immunology, 1989, Vol 29, Issue 3, p371
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1989.tb01136.x