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- Title
Modulation of Human B-Lymphocyte Receptors for IgG Does Not Affect HLA-DR Antigens.
- Authors
Colombatti, M.; Sékaly, P. R.
- Abstract
Receptors for the Fc portion of immunoglobulin G (FcγR) on the surface of human peripheral T cells can be modulated on contact with antigen-antibody immune complexes (IgG-1C). Our results demonstrate that the FcγR present on the surface of human B cells are also modulated on exposure to IgG-IC. Furthermore, the expression of HLA-DR molecules is not affected by the IgG-IC-induced disappearance of FcγR. In fact, the percentage of HLA-DR-positive cells and the relative amount of HLA-DR molecules on individual B cells analysed by flow microfluorometry was shown not to be influenced by FcγR modulation. Moreover, pretreatment of cells with monoclonal antibodies directed against non-polymorphic determinants of HLA-DR antigens did not prevent the binding of IgG-coated ox erythrocytes. These results argue against a structural relationship between FcγR and HLA-DR molecules on the surface of the B-cell populations investigated here.
- Subjects
IMMUNOGLOBULIN G; PLASMA cells; BLOOD proteins; LYMPHOCYTES; B cells; CELL-mediated lympholysis
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 4, p349
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00658.x