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- Title
Contrast-enhanced ultrasound for monitoring effects of extracorporeal shock wave sialolithotripsy in sialolithiasis.
- Authors
Siedek, Vanessa; Clevert, Dirk-André; Rytvina, Margarita; Ihrler, Stephan; Klotz, Laura V.; Berghaus, Alexander; Strieth, Sebastian
- Abstract
Objectives/Hypothesis: Contrast-enhanced ultrasound (CE-US) can be used for noninvasive analysis of functional vascularization. Chronically recurrent sialadenitis due to sialolithiasis of the submandibular gland is associated with increased vascularity. The aim of this investigator-initiated clinical trial was the evaluation of CE-US as a quantitative monitoring technique during gland-preserving extracorporeal shock wave sialolithotripsy (ESWL). Study Design: In this prospective clinical evidence level 2c study, perfusion in patients (n = 10) with unilateral sialolithiasis of the submandibular gland was quantitatively analyzed using CE-US before and after ESWL, comparing with the respective contralateral gland. Methods: Before CE-US measurements, a subjective clinical score of complaints (range, 1-10) was documented. The contrast agent SonoVue was injected into a cubital vein. The intensity-time curve gradients (ITGs) were calculated from CE-US data. Results: The ITGs derived from CE-US measurements revealed higher perfusion in the affected submandibular gland compared to the contralateral side. In parallel to clinical complaints, parametric CE-US data were significantly reduced after ESWL in chronic sialolithiasis-associated sialadenitis. Conclusions: CE-US-derived ITGs appear to be an independent and quantitative marker for treatment effects of ESWL. Clinical experience and further studies will have to validate this method as a diagnostic tool to decide especially whether to proceed to sialoadenectomy in therapy-refractory cases.
- Subjects
SUBMANDIBULAR gland; CLINICAL trials; EXTRACORPOREAL shock wave lithotripsy; VEINS; MEDICAL imaging systems; DIAGNOSIS
- Publication
Laryngoscope, 2012, Vol 122, Issue 6, p1301
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.23281