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- Title
Paediatric Cushing's disease.
- Authors
Storr, Helen L.; Savage, Martin O.
- Abstract
Cushing's disease (CD) is the commonest form of ACTH-dependent Cushing's syndrome and is a rare clinical diagnosis in paediatric and adolescent patients. CD is caused by an ACTH-secreting pituitary corticotroph adenoma and is associated with significant morbidity in children; therefore, early diagnosis and treatment are critical for optimal therapeutic outcome. This review highlights the key clinical and biochemical features of paediatric CD and appraises current practices in diagnosis and management. A close liaison with adult endocrinology colleagues, particularly, for interpretation of investigations and definition of therapeutic strategy is strongly advised.
- Subjects
CUSHING'S syndrome; PEDIATRIC endocrinology; ADRENOCORTICOTROPIC hormone; BIOCHEMISTRY; PITUITARY tumors
- Publication
European Journal of Endocrinology, 2015, Vol 173, Issue 1, pR35
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-15-0013