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- Title
Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy — a retrospective observational study.
- Authors
Fujii, Hironori; Koda, Maaya; Sadaka, Shiori; Ohata, Koichi; Kato-Hayashi, Hiroko; Iihara, Hirotoshi; Kobayashi, Ryo; Ishihara, Takuma; Uemura, Shinya; Iwashita, Takuji; Hayashi, Hideki; Sugiyama, Tadashi; Shimizu, Masahito; Suzuki, Akio
- Abstract
Background: Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between moderate-to-severe AEs and quality of life (QOL) in patients with APC who received outpatient chemotherapy. Methods: We recruited APC patients who received outpatient chemotherapy in Gifu University Hospital between September 2017 and December 2018. Adverse events related to chemotherapy were assessed by a pharmacist collaborating with a physician using common terminology criteria for AEs (CTCAE) ver 4.0, and QOL of patients was self-assessed by patients using the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L Japanese edition 2). Associations between the EQ-5D-5L utility value and serious AEs were assessed using proportional odds logistic regression. Results: A total of 59 patients who received 475 chemotherapy cycles were included. The proportional odds logistic regression indicated that grade ≥ 2 anorexia, pain and peripheral neuropathy were significantly correlated with a decreased EQ-5D-5L utility value. Pharmaceutical intervention for these AEs significantly improved the patients' EQ-5D-5L utility value. Conclusions: Anorexia, pain and peripheral neuropathy were significantly associated with a decrease in QOL. It is assumed that appropriate pharmaceutical intervention with particular emphasis on these AEs can improve the QOL of pancreatic cancer patients receiving outpatient chemotherapy.
- Subjects
PERIPHERAL neuropathy; PANCREATIC cancer; QUALITY of life; OUTPATIENT medical care; CANCER chemotherapy
- Publication
Journal of Pharmaceutical Health Care & Sciences, 2021, Vol 7, Issue 1, p1
- ISSN
2055-0294
- Publication type
Article
- DOI
10.1186/s40780-021-00210-1