We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuroprotective Effect of Diphenyl Diselenide in a Experimental Stroke Model: Maintenance of Redox System in Mitochondria of Brain Regions.
- Authors
Dobrachinski, Fernando; Silva, Michele; Tassi, Cíntia; Carvalho, Nélson; Dias, Glaecir; Golombieski, Ronaldo; Silva Loreto, Élgion; Rocha, João; Fighera, Michele; Soares, Félix
- Abstract
Acute stroke is a major risk for morbidity and mortality in aging population. Mitochondrion has been the focus of a wide stroke-related research. This study investigated if treatment or pre-treatment with diphenyl diselenide (PhSe) can prevent mitochondrial damage in cerebral structures of rats induced by an ischemia and reperfusion (I/R) model. Adult male Wistar rats were assigned into five experimental groups: sham operation, ischemia/reperfusion, pre-treated + I/R, treated + I/R, and Sham + (PhSe). Neurological score showed the damage caused by I/R, which was partially prevented by (PhSe). Moreover, mitochondria of hippocampus and cortex were impaired by I/R through an increase of reactive oxygen species production, mitochondrial membrane potential (ΔΨm) and electrons flow alteration, activity of complex I deregulation as well as mitochondrial swelling. However, the ischemic damage did not induce an increase in pro-apoptotic proteins expression, but demonstrated an enhanced expression of Hsp70. The mitochondrial redox state was also altered (GSH/GSSG ratio, MnSOD, and GPx activities). Our results revealed that all treatments with (PhSe) significantly reduced the mitochondrial damage induced by I/R. These findings suggest that neuroprotective properties of (PhSe) may be attributed to the maintenance of mitochondrial redox balance.
- Subjects
STROKE-related mortality; STROKE treatment; NEUROPROTECTIVE agents; BRAIN physiology; DIPHENYL diselenide; OXIDATION-reduction reaction
- Publication
Neurotoxicity Research, 2014, Vol 26, Issue 4, p317
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-014-9463-2