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- Title
Combined Hepatocellular-Cholangiocarcinoma With Ductal Plate Malformation Pattern: A Case Report With Molecular Analysis.
- Authors
Moon, Woo Sung; Song, Ji Soo; Yu, Hee Chul; Kim, Kyoung Min; Ahn, Ae Ri
- Abstract
Combined hepatocellular-cholangiocarcinoma with a ductal plate malformation pattern is an extremely rare entity with unelucidated pathogenesis. We present the case of a 60-year-old male patient who underwent a sectionectomy for pre-operative diagnosis of hepatocellular carcinoma based on clinical and image findings. Gross examination of the specimen revealed a well-defined tumor with cystic change measuring 6.7 × 6.2 cm. Microscopically, the lesion had classical features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma exhibited neoplastic glands with irregular-sized dilated lumens, resembling a ductal plate malformation. Postoperative diagnosis was combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern. Next-generation sequencing revealed genomic alteration in 15 genes: CDKN2A, CHD4, CYP2D6, ERBB3, KIR3DL1, KRAS, MDM2, PIM1, STAT6, TPMT amplification, FANCD2, FAT1, FLT4, RASA1, and TP53 point mutation. This is the first case report of molecular alteration in combined hepatocellular-cholangiocarcinoma with ductal plate malformation pattern.
- Subjects
ARNOLD-Chiari deformity; HUMAN abnormalities; NUCLEOTIDE sequencing; HEPATOCELLULAR carcinoma; CYTOCHROME P-450 CYP2D6; STAT proteins
- Publication
International Journal of Surgical Pathology, 2024, Vol 32, Issue 1, p160
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969231168966