We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
5- S-GAD Attenuates Fe-Induced Lipid Peroxidation and Cell Death in a Neuronal Cell Model.
- Authors
Takadera, Tsuneo; Koriyama, Yoshiki; Kimura, Takahito; Kato, Satoru
- Abstract
Iron accumulation in brain is associated with a number of common neurodegenerative disorders. N-β-alanyl-5- S-glutathionyl-3,4-dihydroxyphenylalanine (5- S-GAD), a novel catechol derivative, was isolated from adult flesh fly as a defense substance. We examined the effect of 5- S-GAD on Fe-induced lipid peroxidation and cell death in PC12 cells. Treatment of PC12 cells with Fe (1-20 μM) for 24 h induced lipid peroxidation and cell death in a dose-dependent manner. Butylated hydroxyanisole and α-tocopherol inhibited Fe-induced lipid peroxidation and cell death. 5- S-GAD inhibited Fe-induced lipid peroxidation and cell death. 5- S-GAD protected PC12 cells from Fe-induced cell death possibly by blocking lipid peroxidation.
- Subjects
PEROXIDATION; LIPID metabolism; CELL death; NEURAL stem cells; BIOLOGICAL models; IRON in the body; NEURODEGENERATION
- Publication
Neurotoxicity Research, 2011, Vol 20, Issue 1, p26
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-010-9218-7