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- Title
Clostridium perfringens e-toxin shows structural similarity to the pore-forming toxin aerolysin.
- Authors
Cole, Ambrose R.; Gibert, Maryse; Popoff, Michel; Moss, David S.; Titball, Richard W.; Basak, Ajit K.
- Abstract
e-Toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of e-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.
- Subjects
CLOSTRIDIUM perfringens; CLOSTRIDIUM; TOXINS; AEROMONAS hydrophila; AEROMONAS
- Publication
Nature Structural & Molecular Biology, 2004, Vol 11, Issue 8, p797
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb804