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- Title
Embryo morphology score on day 3 is predictive of implantation and live birth rates.
- Authors
Dennis, Sara J.; Thomas, Michael A.; Williams, Daniel B.; Robins, Jared C.
- Abstract
Purpose : To determine if embryo cleavage state or morphology on day 3 correlates with implantation or live birth rates. A retrospective cohort study of all fresh embryo transfers over 2 years. Methods : Patients were grouped by the average cleavage state and morphology. Cleavage state groups were: <6, ≥6, <8, and ≥8 cells. Morphology groups by average grade were: group 1 (best) = 1, group 2 = >1 ≤ 2, group 3 = > 2 ≤ 3, and group 4 (worst) = > 3≤ 4. Results : The overall implantation rate for 158 cycles was 28.1% with a live birth rate of 37.3%. Morphologic state was highly predictive of both implantation rate and live birth rate. Implantation rates by group were 54.8% (group 1), 30.4% (group 2), 23.8% (group 3), and 11.1% (group 4). Likewise, live birth rates among groups were 61.5, 39, 20, and 21%, respectively. Cleavage state was not predictive of outcome. Conclusions : Embryo grade is highly predictive of implantation and live birth rate and can be used to determine the number of embryos to transfer. Cleavage state is not predictive of outcome.
- Subjects
HUMAN embryos; BIRTH rate; HUMAN reproduction; GENETICS; BIOLOGY
- Publication
Journal of Assisted Reproduction & Genetics, 2006, Vol 23, Issue 4, p171
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-006-9027-3