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- Title
Eficacia y seguridad de la combinación de arbutina 5% + ácido glicólico 10% + ácido kójico 2% en crema contra hidroquinona 4% en el tratamiento del melasma facial en mujeres con fototipo III-IV de Fitzpatrick.
- Authors
Fragoso-Covarrubias, César Efren; Tirado-Sánchez, Andrés; Ponce-Olivera, Rosa María
- Abstract
Background: Melasma is an acquired hyperpigmentation, characterized by symmetrical light to dark brown spots that affects areas of the face exposed to the sun with a variable length. Treatment goals include prevention, reduction in the severity, the affected area and the cosmetic defect. The combination of kojic acid, arbutin and glycolic acid is a novel treatment, having the advantages of depigmentation such as hydroquinone but with fewer side effects. Objective: To compare the effectiveness and security (based on Melasma area and severity index [MASI] and the Spanish-Melasma Quality of life questionnaire [Sp-MelasQoL]) of the combination of kojic acid, arbutin and glycolic acid vs hydroquinone in the treatment of melasma. Material and method: A prospective, randomized, open, single-center study included 63 patients: 33 for A group, who received treatment with the triple combination and 30 for B group who received hydroquinone 4% applied daily at night for three months. A total of three monthly visits were performed, in which the side effects were evaluated. Results: The most frequent clinical pattern of melasma was centrofacial, the average MASI in group A was 10.68 ± 5.19 and 7.32 ± 5.81 in group B (p=.001). In group A, the mean reduction was MASI 7.2 ± 4.22 (2.3-15), while for the B group was 4.98 ± 4.2 MASI. Both results were statistically significant (p=.001). Side effects were erythema, burning and irritation in both groups, mainly in A group. Conclusion: The triple combination was equally effective than hydroquinone, although with more frequently occurrence of side effects.
- Subjects
MEXICO; MELANOSIS; OINTMENTS; MEDICAL research; ARBUTIN; GLYCOLIC acid; HYDROQUINONE; PUBLIC health; THERAPEUTICS
- Publication
Dermatología Revista Mexicana, 2015, Vol 53, Issue 4, p263
- ISSN
0185-4038
- Publication type
Article