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- Title
Does heterogeneity of intracellular Ca dynamics underlie speed tuning of direction-selective responses in starburst amacrine cells?
- Authors
Koizumi, Amane; Poznanski, Roman R.
- Abstract
The starburst amacrine cell (SAC) plays a fundamental role in retinal motion perception. In the vertebrate retina, SAC dendrites have been shown to be directionally selective in terms of their Ca responses for stimuli that move centrifugally from the soma. The mechanism by which SACs show Ca bias for centrifugal motion is yet to be determined with precision. Recent morphological studies support a presynaptic delay in glutamate receptor activation induced Ca release from bipolar cells preferentially contacting SACs. However, bipolar cells are known to be electrotonically coupled so time delays between the bipolar cells that provide input to SACs seem unlikely. Using fluorescent microscopy and imunnostaining, we found that the endoplasmic reticulum (ER) is omnipresent in the soma extending to the distal processes of SACs. Consequently, a working hypothesis on heterogeneity of intracellular Ca dynamics from ER is proposed as a possible explanation for the cause of speed tuning of direction-selective Ca responses in dendrites of SACs.
- Subjects
INTRACELLULAR calcium; MOTION perception (Vision); DENDRITES; VISUAL perception; GLUTAMATE receptors; ENDOPLASMIC reticulum
- Publication
Journal of Integrative Neuroscience, 2015, Vol 14, Issue 4, p503
- ISSN
0219-6352
- Publication type
Article
- DOI
10.1142/S0219635215500259