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- Title
Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection.
- Authors
Kee-Taek Jang; Seung-Mo Hong; Kyu Lee; Jong Lee; Seoung Choi; Jin Heo; Dong Choi; Dongil Choi; Jae Lim
- Abstract
Abstract Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p = 0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.
- Subjects
BILE ducts; BILIARY tract; AMPULLA of Vater; CHOLEDOCHO-duodenal junction
- Publication
Virchows Archiv: European Journal of Pathology, 2008, Vol 453, Issue 6, p589
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-008-0682-x