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- Title
Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography.
- Authors
Yoshiaki Yasuno; Masahiro Yamanari; Keisuke Kawana; Masahiro Miura; Shinichi Fukuda; Shuichi Makita; Shingo Sakai; Tetsuro Oshika
- Abstract
Polarization-sensitive optical coherence tomography (PS-OCT) is known to be advantageous because of its additional tissue-specific contrast of the anterior eye. So far, this advantage has been shown only qualitatively. We evaluate the improved visibility afforded by 3-D PS corneal and anterior eye segment OCT (PS-CAS-OCT) in visualizing the trabecular meshwork (TM) based on statistical evidences. A total of 31 normal subjects participated in this study. The anterior eye segments of both the eyes of the subjects are scanned using a custom-made PS-CAS-OCT and the standard-scattering OCT (S-OCT) and polarization-sensitive phase-retardation OCT (P-OCT) images are obtained. Three graders grade the visibility of the TM using a four-leveled grading system. The intergrader agreement, intermodality differences, and interquadrant dependence of visibility are statistically examined. All three of three combinations of graders show substantial agreement in visibility with P-OCT ( 0.74, 0.70, and 0.68, Spearmans correlation), while only one of three shows substantial agreement with S-OCT ( 0.72). Significant dependence of the visibility on the modality (S-OCT versus P-OCT) and quadrants are found by the analysis of variance. A subsequent Wilcoxon signed-rank test reveals significantly improved visibility. PS-CAS-OCT may become a useful tool for screening angle-closure glaucoma.
- Subjects
OPTICAL polarization; OPTICAL coherence tomography; TISSUES; CONTRAST effect; ANTERIOR eye segment; SCATTERING (Physics)
- Publication
Journal of Biomedical Optics, 2010, Vol 15, Issue 6, p061705
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3499421