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- Title
Impact of Oophorectomy on Survival and Improving Nutritional Status in Ovarian Metastasis from Colorectal Adenocarcinoma.
- Authors
Miyagawa, Yusuke; Kitazawa, Masato; Tokumaru, Shigeo; Nakamura, Satoshi; Koyama, Makoto; Yamamoto, Yuta; Miyazaki, Satoru; Hondo, Nao; Soejima, Yuji
- Abstract
Introduction: Ovarian metastasis of colorectal cancer is known to have a poor prognosis. This study aimed to elucidate the characteristics of patients who underwent oophorectomy for ovarian metastasis from colorectal cancer. Methods: This retrospective study included 16 patients who underwent oophorectomy for colorectal cancer metastasis to the ovary from January 2004 to December 2017. Improvement in patient's symptoms and pre- and postoperative changes in various nutritional and inflammatory indicators were assessed. Survival analysis and identification of prognostic factors were conducted with a median follow-up of 40.7 (5–109) months. Results: Of 16 patients, 12 had (75%) synchronous and 4 (25%) had metachronous metastasis. Fourteen patients were symptomatic but symptoms resolved postoperatively. Thirteen patients (81.3%) had ascites and 5 (31.3%) had pleural effusion on preoperative computed tomography that disappeared after surgery in all cases. The median value of prognostic nutritional factor was significantly increased postoperatively (36.0 [preoperatively] vs. 47.5, p < 0.0001). The median (interquartile range) values for lymphocyte-C-reactive protein ratio were 715.2 (110–2,607) preoperatively and 6,095.2 (1,612.3–14,431.8) postoperatively (p = 0.0214). The median survival of the entire cohort was 60.4 months. The 3-year survival rates for R0 + R1 and R2 cases were 83% and 24% (p = 0.018), respectively. Univariate analysis showed that R2 resection and low postoperative lymphocyte-C-reactive protein ratio were associated with poor prognosis. Conclusions: Oophorectomy for ovarian metastasis from colorectal cancers was safely performed. It improved the patients' symptoms and nutritional status and may result in improved prognosis.
- Subjects
ADENOCARCINOMA; C-reactive protein; STATISTICS; OVARIAN tumors; PLEURAL effusions; INFLAMMATION; PREOPERATIVE period; METASTASIS; RETROSPECTIVE studies; ACQUISITION of data; COLORECTAL cancer; PRE-tests &; post-tests; ASCITES; LYMPHOCYTES; OVARIECTOMY; SURVIVAL analysis (Biometry); MEDICAL records; DESCRIPTIVE statistics; POSTOPERATIVE period; MULTIPLE tumors; COMPUTED tomography; NUTRITIONAL status; LONGITUDINAL method; DISEASE complications
- Publication
Oncology, 2024, Vol 102, Issue 2, p114
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000533599