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- Title
Development of Nanoaptamers Using a Mesoporous Silica Model Labeled with Tc for Cancer Targeting.
- Authors
Sá, Lucas Torres Miranda; Pessoa, Claudia; Meira, Assuero Silva; da Silva, Maria Isabel Pais; Missailidis, Sotiris; Santos-Oliveira, Ralph
- Abstract
The use of mesoporous silica in targeted cancer therapy is increasing daily. The combination of a rigid model of nanoparticles like mesoporous silica and biological compounds with an affinity for oncological diseases is the most promising drug-targeting system nowadays. In this study, we used the mesoporous silica SBA-15 combined with aptamer (functionalized for tumor with MUC1). The results obtained were of interest and showed the formation of the silica mesoporous structure. The impregnation methodology of mesoporous silica with the aptamer was also confirmed. Cytotoxicity results demonstrated that the particle associated with the aptamer has no cytotoxicity. We conclude that although further studies are required, the mesoporous silica nanoparticle model loaded with aptamer is very functional and can be used for other applications, especially in nuclear medicine. Copyright © 2012 S. Karger AG, Basel
- Subjects
NUCLEAR medicine; RADIOPHARMACEUTICALS; APTAMERS; CANCER treatment; NANOPARTICLES; SILICA
- Publication
Oncology, 2012, Vol 82, Issue 4, p213
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000337226