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- Title
Nitric Oxide Regulates Mast Cell-Dependent Cardiac Contractility.
- Authors
Czóbel, M.; Kaszaki, J.; Eszlari, E.; Csonka, E.; Nagy, S.; Boros, M.
- Abstract
It has been shown, that nitric oxide (NO) inhibits MC activation in vitro. In this study researchers assumed that degranulation of myocardial MCs can modify cardiac contractility, and the NO level of the microenvironment influences this process. The mast cell degranulator drug Compound 48/80 was used to investigate the involvement of MCs in regulation of cardiac contractility, and they examined the consequences of exogenous NO supply on Compound 48/80-induced MC degranulation and myocardial contractility changes. The experiments were performed on pentobarbitalanesthetized, thoracotomized dogs. Mean arterial pressure, cardiac output were monitored to calculate total peripheral vascular resistance changes.
- Subjects
NITRIC oxide; MAST cells; DOGS; HEMODYNAMICS; VASCULAR resistance; BLOOD pressure
- Publication
European Surgical Research, 2004, Vol 36, p132
- ISSN
0014-312X
- Publication type
Article