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- Title
Adenosine A2 Receptor Stimulation Ameliorates I/R Injury in NHBD Pigs.
- Authors
Tolba, R. H.; Neumann, S.; Song, S.; Yonezawa, K.; Minor, T.
- Abstract
Organ donor shortage has led to reconsideration for the use of non heart beating donors (NHBDs). The present study was aimed at investigating the putative role of the adenosine A2 receptor for graft viability after cold preservation of NHBD livers in a preclinical large animal model. Cardiac arrest was electrically induced in German Landrace pigs. After 30 minutes the livers were perfused by gravity via the portal vein with 3L of HTK at 4 degree Celsius to which the selective adenosine A2 receptor agonist CGS 21680 was added in half of the experiments. All livers were then stored in HTK for 4-5 hours at 4 degree Celsius and transplanted orthotopically into weight matched litter mates.
- Subjects
ORGAN donation; ORGAN donors; HEART beat; CARDIAC arrest; HEART failure; PORTAL vein
- Publication
European Surgical Research, 2004, Vol 36, p1
- ISSN
0014-312X
- Publication type
Article