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- Title
Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene.
- Authors
Schnieke, Angelika; Harbers, Klaus; Jaenisch, Rudolf
- Abstract
Experimental insertion of a retrovirus into the germ line of mice has resulted in an embryonic recessive lethal mutation. Integration of the proviral genome occurred at the 5′ end of the α1(I) collagen gene, leading to a complete transcriptional block. Developmental arrest of embryos homozygous at the mutated allele coincides with high expression of the gene in normal embryogenesis. Insertion mutagenesis by retroviruses may offer a general approach to the identification and isolation of genes which are transcriptionally active during mammalian development.
- Publication
Nature, 1983, Vol 304, Issue 5924, p315
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/304315a0