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- Title
Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma.
- Authors
Amélia de Souza, Ana; Altemani, Albina; Soares de Araujo, Ney; Novaes Texeira, Lucas; Cavalcanti de Araújo, Vera; Borges Soares, Andresa
- Abstract
Pleomorphic adenoma (PA) is the most common salivary gland neoplasm and, although mostly benign, recurrences, being called recurrent pleomorphic adenoma (RPA) and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA), do occur. Recently, attention has been focused on molecular targeted cancer therapy in various tumors, including salivary gland tumors. The aim of this study was to investigate the role of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in PA, RPA, and CXPA. In total, 20 cases of PA, 18 of RPA, and 7 cases of CXPA were immunohistochemically studied for ER, PR, and HER-2. For evaluation of ER and PR, only nuclear expression and greater than 10% positive cells were regarded as cutoff criteria. HER-2 was evaluated semiquantitatively and graded from 0 to 3+. HER-2 amplification was assessed by chromogenic in situ hybridization (CISH). Tumors were negative for ER, PR, and HER-2 in all cases of PA and RPA. A case of CXPA showed moderate and complete membranous staining, and 6 cases were negative. HER-2 amplification was not observed in any case. In conclusion, the lack of ER, PR, and HER-2 expression in PA, RPA, and CXPA suggests that these proteins are not involved in progression, recurrence, or malignant transformation of PA.
- Subjects
ESTROGEN receptors; EPIDERMAL growth factor; ADENOMA; CANCER relapse; CHROMOGENIC compounds; IMMUNOHISTOCHEMISTRY; IN situ hybridization; ONCOGENES; PROGESTERONE receptors; STAINS &; staining (Microscopy); DISEASE progression; THERAPEUTICS
- Publication
Clinical Pathology, 2019, Vol 12, Issue 1-4, p1
- ISSN
2632-010X
- Publication type
Article
- DOI
10.1177/2632010X19873384