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- Title
275. Immunostimulatory Antigen Loaded Microparticles as Cancer Vaccines.
- Authors
Salem, Aliasger K.; Sandler, Anthony D.; Weiner, George J.; Xueqing Zhang; Baman, Nicki K.; Xiaoyan Zhu; Dahle, Christopher E.
- Abstract
The incidence rate for melanoma since 1973 has more than doubled from 5.7 to 14.31 per 100,000. A significant portion of these patients were not cured by chemotherapy or radiation treatment following resection. Immunotherapeutic treatments that utilize ligands for Toll like receptors (TLRs) has significant potential to treat melanoma. We have demonstrated that we can prepare degradable polymer particles with TLR ligands such as cytosine-phosphorothioate- guanine oligodeoxynucleotide (CpG ODN) motifs entrapped within them and provide functional delivery. We have shown that these microparticles are effeciently taken up by antigen presenting cells (APCs) such as dendritic cells (DCs). We have also shown that the CpG ODN ligands which bind to intracellular TLR9 produce significantly stronger CD8+ responses when they are delivered in biodegradable microparticles in comparison to delivery of CpG ODN in solution. Delivery of the CpG ODN ligands in our microparticle vaccine did not upregulate immunosuppressive molecules and acted as a strong immunotherapeutic treatment in a murine melanoma model.Molecular Therapy (2006) 13, S105–S105; doi: 10.1016/j.ymthe.2006.08.329
- Subjects
MELANOMA; DRUG therapy; DENDRITIC cells; ANTIGENS; VACCINATION; THERAPEUTICS
- Publication
Molecular Therapy, 2006, Vol 13, pS105
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1016/j.ymthe.2006.08.329